Yes, of course there is room for bias. Nobody is claiming this was a scientifically valid experiment.
Note that confirmation bias goes both ways though. As far as I can tell, in order to hold a conviction that there absolutely is no difference in how the mouthpieces perform, we'd need to assume that his belief in the differences between the two mouthpieces is so strong that it has obvious-to-the-listener impact on his playing, or that the player faked all of the (marked) differences between the two - different response, different timbre, different slurring/slotting - and then come up with a plausible reason for why he would do that, when the mouthpiece is a prototype and is not for sale.
I think some combination of factors seems plausible - as Dr G said it may rest against the lips differently due to weight/balance, it may provide different auditory/kinetic feedback to the player which creates a feedback loop with his technique, that extreme amount of mass so close to the point of tone generation may affect the sound somehow (possibly by absorbing certain frequencies, rather than by vibrating, for example).
Also please not that nobody said it was "better" or "worse" just that it was different - so if there is in fact difference between heavier and lighter mouthpieces, it would simply come down to individual preference.