I play an open-holed, in-line-G flute, B foot and neither have, nor had, any problems playing as a result of these configurations. However, when I buy a new flute it's going to be just the opposite, probably. I don't fight the configuration but common sense says that for a doubler the closed hole, off-setG is more comfortable and less prone to player error.
I've read comments such as above on this forum before, but never was totally convinced of the benefits of closed-hole, off-setG flutes until a few weeks ago. I play in a regional wind ensemble with a woman who is quite a good flutist. Additionally, she has supplemented the flute section in a concert band I conduct and I respect her highly. I was talking flute with her and was surprised to notice that she was playing closed-hole/offsetG, which I thought "real pros just wouldn't do. when I asked her about it, she just laughed and said, "Why not? Why bother?" Her endorsement is validation enough for me.