From a mechanical engineering standpoint, I perceive the single radial screw (pointing towards the center of the mp) like a poor solution: by rotating the screw, you tend to mess the reed alignment. Probably FL does a bit better than the good old Links, but still, it isn't the most elegant design. Furthermore, a radial movement is 3 times (3.14) less precise than a tangential screw, when it comes to "feel" the tightness. So, I prefer Vandoren's choice, but also all the more conventional ligs where the screws go "sidewise". Bonade, Selmer, Rico, and the newest Vandoren put the screw(s) ON TOP of the mp, so they don't interfere at all with the reed. My choice. Afterwards, I tend to forget about it, and ... play.
PS: FLs look like a cattle fence around your horn. Not really inspiring...
PS2: from a practical point of view, Rovners are the easiest. Unortunately, THEY DO muffle tone a bit. Selmer's design, to keep the single screw on top, but with a metal body, seems a good compromise. Unfortunately, they only fit HR mps.