Definitely maybe. The biggest factor in intonation problems is the player, not the equipment; however, there are issues that come up based on equipment. For example, many people have problems playing large chamber pieces with MK VI's or small chambered pieces with old Bueschers, or a radical change in your set-up---say going from a Selmer C* with a 3 1/2 Vandoren to a Berg 130/1 with a #2 Fibracell---could wreak havoc with your intonation and and a poorly set-up horn could be a problem as well, though that's not a part of your question.........daryl